What is a remedy such as "Clotrimazole" (ointment)? What is it used for and how should it be used? This is exactly what we will talk about in this article.
Form, description, composition
Ointment "Clotrimazole" - what helps? Before answering this simple question, you should tell what this drug is. As you know, it is intended for skin application. A homogeneous 1% ointment has a white or slightly creamy color, and also contains an active ingredient such as clotrimazole.
In addition to the main component, this medicine also contains auxiliary ingredients in the form of polyethylene oxide 1500, propylene glycol, nipagin (methyl parahydroxybenzoate), polyethylene oxide 400 and methyl paraben.
In what package is Clotrimazole ointment sold (what does this remedy help with, you can find out from the attached instructions)? According to consumers, this tool can be purchased in 30 g aluminum tubes, which are placed in cardboard packs.
Pharmacological characteristics
What is remarkable about the remedy "Clotrimazole" (ointment)? What helps this drug? Experts say that this remedy is an antifungal medication for topical use, which has a wide spectrum of action.
What is the reason for the antimycotic property of this drug? This effect is associated with the active component of the ointment, an imidazole derivative.
After the application of a local medication, there is a violation of the synthesis of ergosterol, which is part of most cell membranes of fungi. This process changes their permeability and then causes cell lysis.
How does the drug "Clotrimazole" (ointment) work? What helps this medication? In high concentrations, the drug acts fungicidal, and in small concentrations - fungistatic.
It should also be noted that this medicine affects not only proliferating cells. According to experts, in fungicidal concentrations, it interacts with mitochondrial and peroxidase enzymes. As a result, there is an increase in the concentration of hydrogen peroxide, which reaches a toxic level. It is this process that contributes to the death of fungal cells.
For which fungi is the drug "Clotrimazole" most effective? What helps this medication? According to the instructions, it works well against dermatophytes, causative agents of multi-colored lichen, mold and yeast-like fungi, as well as the causative agent of erythrasma. It should also be noted that this drug exhibits high antimicrobial activity against staphylococcus, streptococcus, gram-negative bacteria and
Kinetics
Now you know what Clotrimazole (ointment) is? From what this medicine helps, we also told above.
What are the kinetic properties of this drug? Experts say that its active component is rather poorly absorbed through the skin and mucous membranes, and also has almost no systemic effects.
According to the instructions, the concentration of this agent in the deep layers of the epidermis is much higher than that which is necessary to suppress dermatophytes. It should also be noted that when applied externally, the concentration of the drug in the epidermis significantly exceeds the concentration in the subcutaneous tissue and dermis.
The drug "Clotrimazole" (ointment): what helps?
There are a huge number of indications for the use of this tool. Experts say that the drug in question is effective in:
- pityriasis versicolor, erythrasma and superficial candidiasis caused by dermatophytes, as well as mold, yeast and other pathogens and fungi sensitive to the active substance of the drug;
- and skin folds, as well as fungal skin lesions;
- mycoses, which are complicated by secondary pyoderma.
Prohibitions for use
Does Clotrimazole ointment have any contraindications? What helps (the price of the remedy is indicated below) this medication, we told above. As for the prohibitions on its use, they include the following:
With extreme caution, the drug in question is recommended to be used during breastfeeding.
Ointment and cream "Clotrimazole": instruction
This medication is for skin use only. Ointment "Clotrimazole" should be applied in a thin layer on dry and previously cleaned affected areas two or three times a day. For greater effectiveness, the drug must be gently rubbed with soft and massaging movements. Before applying the medication, it is advisable to wash the affected skin with soap with a neutral pH.
The duration of therapy with this agent depends on the severity of the disease, as well as the effectiveness of treatment and the localization of pathological changes.
Dermatomycosis is treated with Clotrimazole ointment for at least 4 weeks, and pityriasis versicolor - 7-22 days.
With fungal lesions of the skin of the legs, it is advisable to continue therapy for another 2 weeks after the elimination of the main signs of the disease.
side effects
In some cases, when using the local drug "Clotrimazole", patients experience the following side effects: itching, tingling at the site of application of the cream, burning, blistering, erythema, swelling, peeling and skin irritation. An allergy in the form of urticaria is also possible.
Overdose symptoms and drug interactions
According to experts, the use of the drug in question in large quantities does not cause any conditions and reactions that are life-threatening for the patient.
As for the interaction of this agent, when it is combined with Amphotericin B, natamycin and nystatin, its effectiveness is significantly reduced.
When using the ointment with other agents, significant negative interactions should not be expected. This is due to the fact that the resorption capacity of the drug in question is very low.
The period of pregnancy and feeding the baby
As mentioned above, in the first trimester of pregnancy, the use of this medication is contraindicated. It should be noted that in the process of experimental and clinical studies it has not been established that the use of the ointment in question during the period of gestation or while breastfeeding the baby in any way has a negative effect on the health of a woman or child. However, only an experienced specialist should decide on the appropriateness of using this tool.
The application of this medication directly to the breast is contraindicated.
Special Information
What you need to know about the effect of a drug such as "Clotrimazole"? Ointment - helps with thrush or not? The instruction says that this remedy is effective against fungi of the genus Candida. Therefore, it is not prohibited to use it against thrush. However, before doing this, you should consult a doctor.
It is not recommended to apply the drug to the skin in the eye area. When treating onychomycosis, it is desirable to ensure that the treated nails are cut short or have an uneven / rough surface, so that the active substance penetrates better into the affected areas.
In people with liver failure, it is necessary to periodically monitor the condition of the liver and its work.
If irritation or symptoms of hypersensitivity appear, treatment with the ointment is stopped. In the absence of a therapeutic effect within 4 weeks, it is necessary to confirm the diagnosis.
Compound
1 g of cream contains:
active substance: clotrimazole 0.01 g
Excipients: benzyl alcohol, cetostearyl alcohol, octyldodecanol, polysorbate 60, sorbitan stearate, synthetic cetaceum (ester cetyl wax), purified water.
Description
Homogeneous mass of white.
Pharmacotherapeutic group
Antifungal agents for external use. Derivatives of imidazole and triazole. CodeATX: [ D01 AC01] .
pharmachologic effect
Clotrimazole inhibits cell growth and division and, depending on the concentration, may have a fungistatic or fungicidal effect. Clotrimazole changes the permeability of the cell membrane by disrupting the synthesis of ergosterol and binding to the phospholipids of the fungal cell wall. Clinical studies have shown that topical treatment of infections with clotrimazole is as effective as other imidazole derivatives such as econazole and ketoconazole.
Clotrimazole inhibits the synthesis of proteins, fats, DNA and polysaccharides, damages cellular nucleic acids and accelerates the excretion of potassium. It can also inhibit the activity of oxidases and peroxidases and the biosynthesis of triglycerides and phospholipids in fungi. At higher concentrations, clotrimazole causes damage to cell membranes through mechanisms independent of sterol synthesis. Clotrimazole prevents the transformation of Candida blastospores albicans into an invasive mycelium. A change in the activity of the cell membrane leads to cell death and depends on the degree of drug exposure to microbial organisms.
Activity spectrum
Clotrimazole is characterized by a wide spectrum of activity. Clotrimazole inhibits the development and destroys dermatophytes (Epidermophyton floccosum, microsporum canis, Trichophyton mentagrophytes, Trichophyton rubrum), yeast (Candida spp., Cryptococcus neoformans) and dimorphic fungi (Coccidioides immity, Histoplasma capsulatum, Paracoccidioides brasiliensis). Also, clotrimazole is active against some gram-positive (Streptococcus, Staphylococcus, Gardnerella vaginalis) and gram negative (Bacteroides) microorganisms.
In vitro clotrimazole inhibits reproduction Corynebacterium and gram-positive cocci (with the exception of enterococci) at concentrations of 0.5-10 µg/ml.
Clotrimazole has a wide spectrum of fungistatic and fungicidal activity in vitro. Its effect on the mycelium of dermatophytes (Trichophyton, microsporum, Epidermophyton) similar to the action of griseofulvin, and the effect on budding fungi (Candida) similar to the activity of polyenes (amphotericin B and nystatin).
Clotrimazole at a concentration below 1 μg / ml inhibits the development of most strains Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum And microsporum canis. Clotrimazole at a concentration of 3 μg / ml inhibits the development of most pathogens Pityrosporum orbiculare, Aspergillus fumigatus, Candida species, including Candida albicans, some strains Staphylococcus aureus And Streptococcus pyogenes, as well as some strains Proteus vulgaris And Salmonella. Clotrimazole works against Sporothrix, Cryptococcus, Cefalosporium And Fusarium. Concentrations above 100 µg/ml are effective against Trichomonas vaginalis.
Mushrooms resistant to clotrimazole are extremely rare; there is data only for individual strains Candida guilliermondii.
No development of resistance has been reported in clotrimazole-sensitive fungi after passage. Candida albicans And Trichophyton mentagrophytes. There are no cases of development of resistance to clotrimazole in strains WITH.albicans, resistant to polyene antibiotics due to chemical mutation.
Pharmacokinetics
When applied topically to the skin, clotrimazole is absorbed by the epidermis. Higher concentrations of clotrimazole are found in the horny and prickly layers of the epidermis, as well as in the papillary and reticular layers of the dermis, however, clotrimazole enters the systemic circulation in small quantities.
Clotrimazole is metabolized in the liver to inactive substances excreted from the body through the kidneys and intestines.
Indications for use
Clotrimazole cream is used for topical treatment
Fungal diseases of the skin: hands and feet, trunk, lower leg and foot, caused by dermatophytes Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum And microsporum canis; pityriasis versicolor caused by Malassezia furfur (Pityrosporum orbiculare or Pityrosporum ovale) ;
Fungal infections of the skin and mucous membranes of the external genitalia (labia, foreskin and glans penis) caused by Candida vulvitis or Candida balanitis.
Contraindications
Hypersensitivity to clotrimazole or excipients of the drug.
Use during pregnancy and lactation
Pregnancy
There are limited data on the use of clotrimazole during pregnancy. Animal studies have not shown a direct or indirect effect on reproductive toxicity. As a precautionary measure, the use of clotrimazole in the first trimester of pregnancy should be avoided.
Lactation
Available pharmacodynamic/pharmacokinetic data in animals have shown excretion of clotrimazole/metabolites into milk. During treatment with clotrimazole, breastfeeding should be discontinued.
Fertility
Studies of the effect of clotrimazole on human fertility have not been conducted. Animal studies have shown no effect on fertility
Dosage and administration
For outdoor use.
The cream should be applied in a thin layer 2-3 times a day on previously cleansed (using neutral pH soap) and dry affected areas for 2-4 weeks.
The cream should be applied simultaneously to all affected areas.
When applying the cream on the feet, they must be thoroughly washed, dried, and then applied to the areas between the toes.
Patients should re-consult a doctor if symptoms do not improve after 7 days of treatment.
Side effect
The frequency of occurrence of adverse reactions is defined as follows: very often (≥ 1/10), often (from ≥ 1/100 to the frequency is unknown (frequency cannot be estimated from the available data).
Immune system disorders:
Frequency unknown: allergic reactions (such as urticaria, shortness of breath, arterial hypotension, fainting).
Skin and subcutaneous tissue disorders:
Frequency unknown: itching, rash, blisters, peeling of the skin, sensation of pain or discomfort, swelling, burning, irritation, erythema, tingling.
If the listed adverse reactions occur, as well as reactions not mentioned in the instructions for medical use, you should contact your doctor.
Overdose
With external use of the drug, an overdose is unlikely.
The use of clotrimazole in high doses does not cause any reactions and conditions that are life-threatening.
The drug is not intended for oral administration. If by chance the cream is taken orally, anorexia, nausea, vomiting, abdominal pain, liver dysfunction are possible; rarely drowsiness, hallucinations, frequent urination, allergic skin reactions. In this case, it is necessary to carry out a gastric lavage and prescribe activated charcoal.
In case of accidental contact of the cream with the eyes or mouth, immediately rinse them with water and consult a doctor as soon as possible.
If the cream is swallowed, you should immediately consult a doctor.
In the instructions for use of Clotrimazole ointment, it is recommended to use it for the treatment of thrush in women. The disease develops with a sharp decrease in immunity and is manifested by severe symptoms. Particular discomfort is caused by pain and burning, pain in the lower abdomen, vaginal discharge. The use of systemic antimycotic agents often leads to adverse reactions. Therefore, doctors prescribe women drugs for topical use.
Clotrimazole ointment is often included in the therapeutic regimens of patients with thrush (vaginal candidiasis). It not only eliminates the symptoms, but also affects the cause of the disease - Candida yeast-like fungi. The drug is available, it is not expensive, it is convenient for treatment at home.
Clotrimazole ointment is a time-tested remedy against thrush. This infection of the genital organs often develops with endocrine pathologies, hypothermia, and prolonged use of antibiotics. With the weakening of the body's defenses, pathogens of mycoses begin to become more active. Candida fungi belong to the opportunistic microflora and are always present in the vagina in small quantities. Against the background of a decrease in immunity, they begin to multiply rapidly and affect the mucous membranes. If at this stage you use Clotrimazole ointment, then you can do without taking systemic antimycotics. The drug quickly eliminates the symptoms of thrush:
- burning and itching in the vagina;
- redness, swelling, itching;
- pain during and after urination;
- curdled discharge from the genitals.
The drug helps to quickly get rid of the symptoms of chronic vaginal candidiasis. With this form of pathology, there is rarely a discharge of thick mucus from the vagina. Women suffer from excessive dryness of the mucous membrane, hyperemia, dry erosion.
Even after a single application of an antifungal agent, the intensity of clinical manifestations decreases.
To enhance the therapeutic effect of the ointment, the doctor may prescribe the simultaneous use of other drugs. The action of Clotrimazole is enhanced by immunomodulators, immunostimulants, balanced complexes of vitamins and microelements.
Pharmacotherapeutic group and action
Clotrimazole ointment is used for the effective treatment of genital candidiasis. Its antifungal action is based on the pharmacological properties of the active ingredient, an imidazole derivative. To build cell membranes, pathogenic fungi produce the organic compound ergosterol. Clotrimazole blocks enzymes that stimulate its biosynthesis and prevents the spread of infection. Under the action of the ointment, the permeability of the membranes changes, so the cell gradually dissolves. The drug exhibits antimycotic activity against such pathogenic fungi:
- dermatophytes;
- yeast-like and mold fungi;
- causative agents of multi-colored lichen.
When using the drug in small doses, it has a fungistatic effect, preventing damage to healthy tissues. And the frequent use of Clotrimazole ointment in large quantities helps to completely destroy the pathogens of thrush. The active ingredient enters into biochemical reactions with enzymes, increasing the concentration of hydrogen peroxide. Such an environment is toxic to fungi, causing the destruction of their cells.
After applying the product to the vaginal mucosa, about 5-10% of the active substance of the ointment is absorbed. It is metabolized by liver cells and evacuated from the human body along with bile.
Release form, composition and packaging
On the pharmacy counters there is Clotrimazole ointment from Russian, Indian Polish manufacturers. The products of domestic pharmaceutical factories are much cheaper, varying between 20-30 rubles. The price of an imported drug can exceed 80-100 rubles. The drug is produced in the form of a 1% ointment of a jelly-like consistency without a characteristic odor. In addition to the active ingredient, it contains the following auxiliary chemical compounds:
- propylene glycol;
- polyethylene oxide;
- methylparaben;
- nipagin;
- cetostearyl alcohol;
- glycerol
- Castor oil;
- distilled water.
Auxiliary components enhance and prolong the clinical action of Clotrimazole. They create a pH environment as close as possible to the acidity of human skin and mucous membranes. Propylene glycol ensures maximum absorption of the active ingredient, its uniform distribution in tissues. And castor oil moisturizes the mucous membranes, accelerating their regeneration. Cetostearyl alcohol is added to the composition, from which Clotrimazole ointment helps women eliminate unbearable itching.
The external agent is packaged in aluminum tubes of 15.0 g, 20.0 g, 30.0 g, 40.0 g. The secondary packaging is a cardboard box with instructions for use enclosed inside.
Instructions for use for women
To start using Clotrimazole ointment in women with thrush should be at the first clinical manifestations. During the treatment of vaginal candidiasis, it is necessary to refuse sexual intercourse. Otherwise, there is a high risk of re-infection from a partner.
The instructions for use of Clotrimazole ointment in gynecology recommend the simultaneous use of drugs to increase immunity. With a low resistance of the body, a new relapse of thrush is possible. The use of immunostimulants with an antimycotic agent (Immunal, echinacea tinctures, ginseng) will completely get rid of the disease.
Indications for use
Doctors prescribe Clotrimazole in the form of an ointment for the treatment of vaginal candidiasis at any stage of the pathology. It is used both for therapy and as a prophylactic. The drug for application to the vaginal mucosa destroys fungal pathogens and prevents exacerbations of thrush.
Clotrimazole ointment relieves a woman of severe discomfort - burning from itching in intimate places.
It is appointed by gynecologists and for the following purposes:
- prevention of activation of pathogenic fungi while taking systemic antibacterial drugs;
- prevention of the development of thrush in women with immunodeficiency conditions.
Clotrimazole ointment is injected into the vagina before childbirth when vaginal candidiasis is detected in the mother. It sanitizes the mucous membranes and prevents infection of the child during passage through the birth canal.
Clotrimazole for thrush
This is one of the most affordable and commonly used remedies for the treatment of vaginal candidiasis. The therapeutic line of Clotrimazole includes: solution, cream, gel, vaginal suppositories and tablets. When diagnosing thrush of moderate and high severity, drugs are combined. The combination worked well:
- tablets for insertion into the vagina and preparations for application to the mucous membranes;
- vaginal suppositories with cream or gel.
In the treatment of complicated thrush in women, the doctor prescribes for the rapid elimination of symptoms: Clotrimazole and Fluconazole. This technique can significantly speed up recovery and avoid relapses against the background of reduced immunity.
The use of Clotrimazole ointment for thrush in women is suspended during menstruation. At this time, you can use vaginal tablets or suppositories. Doctors strongly recommend refraining from douching during the treatment of candidiasis, which contribute to the spread of infection. Be sure to treat the sexual partner with antimycotics for external and internal use.
Contraindications and side effects
An absolute contraindication to the use of any dosage form of Clotrimazole is individual sensitivity to the components. It may not be the active ingredient, but substances used to form tablets or creams. An external agent should be used with caution in the presence of severe pathologies of the liver and urinary organs. Side effects of the drug include:
- burning and hyperemia;
- swelling of the epithelium;
- the appearance of rashes.
After intravaginal use of Clotrimazole, in addition to the above symptoms, in rare cases, urination becomes more frequent. Swelling and hyperemia of the mucous membranes causes a feeling of dryness and itching. Ingoda increases the volume of curdled vaginal discharge. After consultation with a gynecologist, it is possible to adjust the dosages or replace the drug with an analogue.
Use during pregnancy and lactation
Clotrimazole ointment, gel or cream for thrush is prescribed by gynecologists only in the 2nd and 3rd trimesters of pregnancy. According to the results of clinical trials in the later stages, the drug does not have a teratogenic effect. Despite the relative safety during therapy, the patient is shown regular laboratory blood control.
A small amount of the active ingredient enters the systemic circulation. There is a possibility of its accumulation in breast milk. Therefore, it is better not to use any dosage forms of Clotrimazole during breastfeeding.
Dosage and administration
Daily and single doses for vaginal administration of Clotrimazole are determined by the attending physician. Equally important are the stage of the course of the pathology and the degree of damage to the mucous membranes. The average dose is approximately 5 mm of the product squeezed out of the tube. How to use Clotrimazole ointment or cream for thrush in women:
- before the treatment procedure, it is necessary to wash the genitals with hygiene products and dry with a towel;
- apply the ointment not only to the area of inflammation, but also to adjacent healthy tissues.
Depending on the stage of the pathology and the number of developed complications, gynecologists recommend using the drug 1-3 times a day.
You can not stop treatment after the disappearance of symptoms of vaginal candidiasis. Therapy is carried out until the absence of pathogens is established in the biological sample. To prevent the development of adverse reactions, it is necessary to dose the medicine correctly.
Application features
Clotrimazole for the treatment of the intimate area is used as monotherapy or as part of a complex treatment. During its use, you should stop wearing synthetic underwear. The following medical recommendations will help speed up recovery:
- the use of 2-2.5 fluids daily to remove the products of the inflammatory process from the body;
- exclusion from the diet of foods high in sugar, provoking the rapid reproduction of pathogenic fungi.
Cream Clotrimazole refers to antifungal agents. Designed for the treatment of skin diseases. The drug has several forms of release - cream, ointment, tablets, suppositories, solution for douching. Each of them has its own application features. The drug has a detrimental effect on pathological microorganisms, prevents the spread of infection.
The active ingredient of Clotrimazole cream is the substance of the same name - clotrimazole. Action depends on concentration. Either slows down and stops the growth of pathological microorganisms, or leads to their death. The substance is characterized by a wide spectrum of action.
- Fungi;
- bacteria;
- Protozoa;
- Dermatophytes;
- Yeast.
Pathogenic microorganisms do not show resistance to the active ingredient. The action of the drug always causes their death.
The main advantage of clotrimazole is its concentration in skin tissues. The substance practically does not penetrate into the bloodstream, focuses on problem areas. This reduces the risk of side effects.
Auxiliary components of the drug:
- Benzyl, cetostearyl alcohol;
- Polysorbate;
- Octyldodecanol;
- Sorbitan stearate;
- Water;
- Synthetic spermaceti.
The cream has a lightweight texture, is well applied, quickly absorbed, and practically odorless. Metabolism occurs in the liver, excreted from the body by the kidneys, through the intestines.
What helps the cream - indications for use
An antifungal drug with a wide spectrum of action has found application in dermatology, gynecology, and some other areas. The drug for external use is prescribed for:
Clotrimazole can be used by women and men. The course of therapy is prescribed by a doctor, regulates the concentration of the active component with different forms of the drug.
Application features
Clotrimazole cream is recommended to be applied in a thin layer on previously cleansed, dried skin. The procedure is carried out 2-3 times a day. The duration of therapy depends on the extent of the lesion, localization. On average, treatment lasts 1 month. It is not recommended to stop therapy immediately after the disappearance of painful symptoms. In order to consolidate the effect, the drug is used for another 1-2 weeks.
The use of clotrimazole for men
One of the indications is thrush. Mushrooms of the genus Candida are often detected in women, although the main carrier of the disease is the man. In them, thrush is asymptomatic or has mild symptoms:
Clotrimazole is considered one of the most effective remedies for male thrush. The drug is applied in a thin layer on the head of the penis twice a day after water procedures. The duration of therapy is 2 weeks. To consolidate the result, it is recommended to extend the course for 7 days.
Another disease that is more characteristic of men is foot fungus. Main symptoms:
- Itching, burning;
- peeling of the skin;
- Redness;
- Wet between fingers;
- Erosion at the site of previous cracks;
- Loosening of the skin.
The disease is dangerous due to a decrease in local immunity, the addition of a secondary infection.
Clotrimazole is used after preliminary cleansing of the skin of the foot. Apply a thin layer twice a day. The drug quickly stops the symptoms, destroys the source of the disease.
Contraindications
Since the active ingredient does not penetrate into the bloodstream, the cream does not affect the functioning of internal organs and systems. The only contraindication is individual intolerance to the components. A test is recommended before active treatment. A small amount of cream is applied to the elbow bend, the skin condition is observed for 1 hour.
Side effects occur in the presence of individual intolerance. Manifested in the form of rashes, redness on the skin. They go away on their own without special treatment.
In the course of laboratory studies, no negative effect of Clotrimazole cream on the body of a pregnant woman, the development of the fetus was found. However, use during pregnancy, breastfeeding should be under 
careful supervision of experts.
The price of the drug
The cream is produced by several manufacturers, including Russia, under license from a UK company. Therefore, the prices are different. The budget version of the drug is produced by Sedate Helskar. For a tube of cream with a capacity of 20 ml, you will have to pay 39 rubles. The most expensive drug is presented by GlaxoSmithKline Pharmaceuticals S.A.. The cost of a cream with the same capacity is 170 rubles. The drug can be bought at a pharmacy or ordered online. The shelf life is 3 years from the date of manufacture.
What is the difference between Clotrimazole cream and ointment
The concentration of the active ingredient is similar to the cream. So, the ointment works in the same way. The composition of excipients differs insignificantly. Due to this, the ointment has a denser consistency. With complex fungal infections of the skin, mucous membranes, it is recommended to initially treat with an ointment, then switch to a cream.
Cream analogues Clotrimazole
Antifungals are one of the largest pharmaceutical groups. Clotrimazole has analogues in composition, action.
Cream generics, that is, drugs with an identical active ingredient, practically do not differ in price, composition, and action. The pharmacy may offer:
Antifungal drugs with a similar effect:
- Pimafucin;
- Nystatin ointment;
- Ketozoral;
- Miconazole;
- Dactanol;
- Ketoconazole.
When choosing a drug, you should be guided by the recommendations of the attending physician. Drugs are dispensed without a prescription.
Instructions for use:
Clotrimazole is a widely used synthetic antifungal drug for external use.
pharmachologic effect
The active substance Clotrimazole has an antifungal effect against:
- Candidaalbicans;
- Malasseziafurfur;
- Cryptococcus neoformans;
- Coccidioidesimmitis;
- Trichophyton;
- Blastomyces dermatitidis;
- Sporothrix schenckii;
- epidermophyton;
- microsporum;
- Aspergillus.
According to the instructions, Clotrimazole has a very high penetrating power and also exhibits antitrichomonas, antibacterial (gram-positive microorganisms, in particular, staphylococci, streptococci, and less pronounced corynebacteria) and antiamebic (cysts of pathogenic negleria) action.
Release form
Clotrimazole is produced in various dosage forms:
- White, biconvex, homogeneous, parallelepiped-shaped vaginal tablets with rounded edges Clotrimazole vaginal tablets (Clotrimazole suppositories) containing 100 mg of the active substance - clotrimazole. 6 pieces in a blister;
- White homogeneous antifungal ointment Clotrimazole for external use. 1 g of ointment contains 10 mg of active ingredient. In tubes of 30 g;
- 1% cream Clotrimazole, applied externally, in tubes of 20 g;
- 2% cream Clotrimazole vaginal, in tubes of 50 g;
- 1% solution for external use in orange bottles, 15 ml and 30 ml.
Indications for use Clotrimazole
According to the instructions, Clotrimazole is used for fungal diseases of the skin, mucous membranes, mycoses of skin folds and feet:
- Epidermophytosis;
- Erythrasma;
- Dermatomycosis;
- Genital infections and superinfections (vulvovaginal candidiasis, trichomoniasis);
- Candidiasis;
- Superficial candidiasis caused by various types of fungi sensitive to clotrimazole;
- Dermatophytosis;
- stomatitis;
- Mycoses complicated by secondary pyoderma;
- Pityriasis versicolor;
- Microsporia.
Candles Clotrimazole (Clotrimazole vaginal tablets) is used to sanitize the birth canal before childbirth, as well as to prevent infection before genital surgery.
Contraindications
Clotrimazole has a small list of contraindications.
The drug is not used in case of hypersensitivity to clotrimazole or other components of the drug, as well as in the first trimester of pregnancy.
In the second or third trimesters of pregnancy and during lactation, Clotrimazole tablets are used with caution strictly according to indications.
Instructions for use Clotrimazole
Clotrimazole vaginal tablets are usually injected into the vagina in the evening, as deep as possible in the supine position. To do this, use the applicator included in the package. The course is - 1 candle Clotrimazole daily for 6 days.
Repeated treatment with Clotrimazole is prescribed by a doctor.
With candidal vulvitis or candidal balanitis, suppositories are used simultaneously with Clotrimazole cream, which is applied externally several times a day to the affected areas for one to two weeks. With trichomoniasis, it is recommended to combine the use of Clotrimazole suppositories with chemotherapeutic drugs inside (metronidazole).
Clotrimazole ointment for external use is applied to clean, affected areas of the skin with a thin layer several times a day, gently rubbing. The duration of treatment depends on the location, severity of the disease and the effectiveness of therapy:
- Dermatomycosis is treated for at least a month;
- Pityriasis versicolor - up to three weeks;
- Fungal diseases of the skin of the legs - therapy is continued for at least two weeks after the symptoms have passed.
Clotrimazole cream can also be used to treat these diseases.
After applying Clotrimazole ointment, sealing dressings should not be applied.
Side effects
With external use of Clotrimazole ointment, edema may occur, as well as burning, peeling or skin irritation, itching, erythematous rashes, paresthesia, blistering or urticaria.
When using Clotrimazole suppositories, burning, itching, swelling of the mucous membrane are possible. Also, sometimes when using Clotrimazole suppositories, according to the instructions, vaginal discharge appears, urination becomes more frequent, intercurrent cystitis occurs, and pain during intercourse and a burning sensation in the partner's penis may also occur.
According to reviews, with frequent use of Clotrimazole cream, headache and gastralgia may occur.
Storage conditions
Clotrimazole is available without a prescription.